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Pfizer Inc. ignored a 2005 FDA Warning Letter to stop promoting its antibiotic Zyvox(R) as clinically superior to the significantly less expensive, generic vancomycin when its own FDA-approved label indicated otherwise. The drug giant also defrauded federal and state taxpayers by marketing Zyvox off-label, according to a qui tam whistleblower complaint filed by Philadelphia law firm Sheller, P.C. and other documents unsealed with today's $2.3 billion Pfizer settlement.

The $2.3 billion settlement included off-label marketing allegations for the withdrawn arthritis drug Bextra(R), which was included in the Sheller complaint. Zyvox (linezolid) is an antibacterial agent that is approved by the FDA to treat certain types of infections, including nosocomial pneumonia and complicated skin and skin structure infections ("CSSSIs") due to Methicillin Resistant Staphylococcus Aureus ("MRSA"). Worldwide sales of Zyvox totaled $1.115 billion in 2008.

The largest pharmaceutical qui tam whistleblower settlement in history, the $2.3 billion settlement was announced today by the U.S. Department of Justice and the U.S. Attorney's Office for the District of Massachusetts.

Stephen A. Sheller, Esq., named partner of the Philadelphia firm earlier this year, represented a relator, the legal term for a whistleblower, in the largest single-drug whistleblower case in U.S. history when Eli Lilly & Company paid $1.4 billion to settle Zyprexa(R) off-label marketing allegations. The Sheller firm's lawyers have previously represented several other whistleblowers in successful lawsuits.

Approximately $4.4 billion worth of Pfizer's Zyvox was sold from 2000 to 2008, according to the company's annual reports. Explosive sales increases averaged close to 200 percent per year. They also caused public health concerns of drug resistance and immunity, according to court and public documents.

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"The widespread off-label promotion of Zyvox by Pfizer for non-FDA approved purposes poses a grave public risk because it increases the risk that linezolid resistant eterococci will develop and also increases the risk that more Zyvox resistant bacterial strains will develop," according to Sheller's complaint.

Schizoaffective Disorder - Causes, Symptoms and Treatment

Schizoaffective Disorder is one of many disorders which are very tough to recognize. Very often, when it passes through the mind of the patient it has two effects-

· Psychotic disorders

· Mood swings

These two conditions however, differ in intensity and the time period in which it prolongs. It is the mood swing which lasts for a longer time. This disorder is tough to recognize because the symptoms are similar to other disorder and the most prominent symptoms are from the psychotic disorder. Even depression is a very important factor which helps in the diagnosis of the Schizoaffective Disorder.

While the psychiatrist is diagnosing the patient, he must find at least two major symptoms in order to confirm that the patient has the disorder. This disorder includes the symptoms of a psychic disorder such as hallucination, delusion, and catatonic behavior. Similarly the speech of the patient cannot be understood by anyone and it makes no sense for them. The patient also loses interest in any normal activity and does not even bother to keep himself hygienic. Their behavior in public can be much unexpected. They have the capability of undressing in front of a huge crowd when they are under the influence of the Schizoaffective Disorder. This is done by them in order to gain attention, cause shame to the onlookers or to see the expression of shock in people. These patients tend to get very emotional and can go into depression and the mood swings that occur are very extreme. The patient can even act fanatic at times.